Spanish conquistadors were the first Europeans to reach Tennessee, followed by the French and English explorers, and then by the first white settlers. Armor and weapons from the Europeans and Daniel Boone's musket highlight this era.

A frontier cabin, 200-year-old dugout canoe, a grist mill, and a Conestoga wagon all give testimony to life on the frontier. Handmade furniture, a woodworking shop, and a working printing press show the skill of early Tennessee craftspeople.
Moccasins presented to James Robertson during treaty ceremonies with the Chickasaw Indians.